Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation on an hidden munitions depot in Syria employed by the IS group, according to the British defence ministry.
The facility, located using reconnaissance, was believed to be storing arms and explosives, the announcement noted, and was positioned in mountains just above the historic site of Palmyra in central Syria.
"Our aircraft used Paveway IV guided bombs to hit a number of entry passages providing entry to the site... early reports suggest the objective was successfully hit," the ministry announced.
There was no evidence of any civilian impact in the attack conducted Saturday night and every plane involved made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as the so-called Islamic State - established extremist governance over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and resolve to stand shoulder to shoulder with our partners, to eliminate any resurgence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary John Healey said.
UK warplanes have conducted overwatch operations over Syrian airspace to "prevent any efforts to regroup" of the group subsequent to its defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of the UK armed forces involved in this strike for their professionalism and their valour," he commented. "They were among thousands of British troops stationed over the festive period. This mission, to remove dangerous terrorists who endanger our safety, highlights how UK forces are ready to step up, continuously, protecting the UK at home and influential overseas."
Last December, the United States armed forces conducted what it called a "large-scale strike" against IS targets in Syria, after an attack killed two US troops and a local interpreter in the Palmyra area.
The UN reports Islamic State still boasts between 5,000 and 7,000 fighters in Iraq and Syria.
